The present study was carried out to investigate the effect of ethanolic extract of Ixoracoccinea (Family: Rubiaceae)on calcium oxalate crystallization in urolithiasis. Calcium oxalate crystallization was induced by the addition of0.01M sodium oxalate solutions in synthetic urine. The effect of various concentrations of extract (50, 100, 150, 200and 250 μg/ml) was studied by measurement of turbidity in presence or absence of inhibitor (extract) at 620 nm afterten minutes by means of a spectrophotometer.Phytochemical investigation of ethanolic extract ofIxoracoccinealeaves revealed the presence of alkaloids, glycosides, proteins, tannins, flavonoids, carbohydrates andcoumarins. HPTLC analysis confirms the presence of phytoconstituents. The hydroalcoholic extract of leaves ofIxoracoccineahas inhibitory effect on Calcium Oxalate crystallization.Key Words: Ixoracoccinea, anti urolithiatic activity, hydroalcoholic extract

GlycosmisarboreaDC is a medicinal plant widely used in traditional systems of medicine for the treatment of arthritis.To evaluate the anti-arthritic efficacy, the chloroform, ethyl acetate and ethanol extracts of roots of Glycosmisarboreawere taken and screened by bovin serum albumin denaturation method. The results indicated that all the extractstested, have shown positive response, with the ethanol extract exhibiting maximum efficacy of 48.46%,whencompared with standard drug, diclofenac sodium with 55.92 % inhibition at 10 μg/ml. The effect of different extractswere in the order of ethanol > ethyl acetate > chloroform.Key Words: Glycosmisarborea, anti-arthritic efficacy

In the present study, the flavonoids viz. Quercetin and Kaempferol were selected and formulated in different ratiosand were screened for Antioxidant andAnti-dermatophyte activities.The gel was prepared in different ratios like 1:2,1:1 and 2:1 of QuercetinKaempferol& among them the 1:1 ratio of Quercetin: Kaempferol has a good response. Theprepared various combinations of gels were evaluated for various physicochemical properties. From the results it isclearly evident that all the gel formulations showed good gelling property and homogeneity. The pH of all theformulation was in the range of 6.60 to 7.33, which lies in the normal pH range of the skin.Formulation was showedzone of clearance and percentage of inhibition at higher concentration (1000 μg) against human pathogenicdermatophyte. Maximum zone of inhibition exhibited formulation of differentorganisms:Trichophytonmentagrophtye (19 mm) and Trichophytonrubrum(18 mm).Key Words: Quercetin, Kaempferol, Anti-dermatophyte activities

The present study has been under taken with main objective of evaluating the aqueous extract of leaves ofLanneacoromandalicafor antiulcer activity using rat as an experimental animal model. In aspirin plus pylorus ligationinduced ulcer model, the methanolic extract of leaves of Lanneacoramandelica at doses of 200mg/kg and 400mg/kgP.O were found to be having significant, graded and dose dependent anti ulcer and anti secretory activity whencompared to control group using ranitidine 50mg/kg as standard.Key Words: methanolic extract, Lanneacoramandelica, antiulcer activity

A simple and selective HPLC method is described for the determination of Atomoxetine.Chromatographic separationwas achieved on a C18column using mobile phase consisting of a mixture of 40 volumes of Methanol, 40 volumes ofAcetonitrile and 20 volumes of Water with detection of 253 nm. Linearity was observed in the range 50-150 μg /mlfor Atomoxetine (r2 =0.990) for the amount of drugs estimated by the proposed methods was in good agreement withthe label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studiesat three different levels. Recovery experiments indicated the absence of interference from commonly encounteredpharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing%RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis ofpharmaceutical dosage form.Key Words: Atomoxetine, HPLC method

Loratadineis a try - cyclic anti- histamine, which has a selective and peripheral H1 antagonist action.It is effective inrelieving nasal congestion, particularly in patients with allergic rhinitis. In present work an attempt has been madeto prepare fast dissolving tablets of loratadine with increased rate of dissolution may leads to increasebioavailability. In present work fast dissolving tablet of loratadine prepared using croscamellose sodium, sodiumstarch glycolate and cross-povidone as superdisintegrants by direct compression method. The tablets wereevaluated for various parameters like weight variation, hardness, friability, in vitro disintegration time, drugpolymerinteraction, drug content water absorption ratio, wetting time, in vitro drug release, FTIR studies and shortterm stability studies.The tablet prepared by direct compression method passes weight variation was found in therange 201.6 to 205.6 mg which is below ±7.5%, hardness 3.5 to 5 Kg /cm2, percentage friability of 0.23 to 0.54 %,in vitro disintegration time of 2 to 7 min, drug content uniformity was in between 98.02 to 98.75%, FTIR studyshowed that there was no drug interaction with formulation additives of the tablet, short term stability studies of theformulations indicated that there are no significant change in hardness, friability, drug content and in vitro drugrelease. (p<0.05).Key Words: Loratadine, direct compression method, in vitro drug release

A simple and selective LC method is described for the determination of Tinidazole and Diloxanide furoate in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 30 volumes of Mixed Phosphate buffer (KH2PO4+K2HPO4) pH 6.5 and 70 volumes of Acetonitrile with detection of 270 nm. Linearity was observed in the range 36-84 µg /ml for Tinidazole (r2 =0.9987) and 30-70µg /ml for Diloxanide furoate (r2 =0.9977) for drugs estimated by the proposed methods was in good agreement with the label claim.The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form. Key Words: Tinidazole, Diloxanide furoate, tablet dosage forms

A simple and selective HPLC method is described for the determination ofAtomoxetineChromatographic separation was achieved on a C18column using mobile phase consisting of a mixture of 40 volumes of Methanol, 40 volumes of Acetonitrile and 20 volumes of Water with detection of 253 nm. Linearity was observed in the range 50-150 µg /ml for Atomoxetine (r2 =0.990) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form. Key Words: Atomoxetine, HPLC method

In the present work, Subligualtablets of Carvedilol were prepared by direct compression method. IR-spectroscopic studies indicated that there are no drug–excipients interactions. All the tablets were subjected to weight variation, drug content uniformity, and hardness, and friability, water absorption ratio, wetting time, dissolution, drug excipients interaction and short-term stability studies. The hardness of the prepared tablets was found to be in the range of 3.0 to 3.4 kg/ cm2 . Thefriability values were found to be in the range of 0.33 to 0.47 %.Disintegration time was found to be in the range of 1-3min. Formulation C3 showed good results than rest of the other formulations in pre and post compression studies. The average weight and drug content of the prepared tablets indicate weight and drug content uniformity within the batches prepared. Formulation C3 (101) displayed maximum drug release. Key Words: Subligualtablets, Carvedilol

The present study has been a satisfactory attempt to formulate floating microspheres of Docetaxel, a new anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian and non-small cell lung cancer.
From the experimental results it can be concluded that,FT-IR study shows no significant shifting of the peakstherefore it confirms the short term stability of the drug in the beads. Biocompatible polymers like can be chitosanand albumin used to formulate microspheres. Good percentage drug entrapment and practical yields were obtainedwith both the polymers. Theflowpropertiesofallformulationswerewithintheacceptablerangeand therefore they couldbe easily filled into capsules. Cumulative percentage drug release significantly decreased within creasein polymerconcentration. The overall curve fitting in to various mathematical models was found to be on anaverage. Theformulations D7 best fitted in to first order kinetic model and Higuchi model. Thus, the formulated microspheresseem to be a potential candidateas an oral controlled drug delivery system in prolonging the drug release andincreasing the bioavailability of drug.Key Words: floating microspheres, Docetaxel

OBJECTIVE:To evaluate the additive antibacterial and antioxidant activity of ethanolic mixture of Emblica officinalis and Azadirachtaindica leaf extract.METHOD: The ethanolic extraction of Amla and Neem leaf was carried out by using cold maceration method. The technique of disc diffusion was implemented to evaluate the in-vitro antibacterial activity against E. coli and B.subtilis.The in-vitroantioxidant activity of varying concentrations of 20, 40, 60, 80, and 100μg/ml was analyzed using the DPPH free radical scavenging method.RESULT:The in-vitro antibacterial activity of combined leaf extract determined by measuring the zone of inhibition. It shows additive antibacterial activity against the tested organism. The in-vitro antioxidant activity shows synergistic effect on ethanolic mixture of leaf extract in a dose dependent manner.CONCLUSION: The present study concludes that the ethanolic mixture of E.officinalis and A.indica leaf extractposses additive antibacterial effect and synergistic antioxidant activity.KEYWORDS:Antibacterial, Antioxidant, Ethanolic extract, Disc diffusion method, DPPH assay.