A simple and selective LC method is described for the determination of Deferiprone dosage forms.
Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of
Triethylamine (pH 3.5): ACN (50:40v/v), with detection of 280 nm. Linearity was observed in the range 125-
375 μg /ml for Deferiprone (r2 =0.994) for the amount of drugs estimated by the proposed methods was in
good agreement with the label claim. The proposed methods were validated. The accuracy of the methods was
assessed by recovery studies at three different levels. Recovery experiments indicated the absence of
interference from commonly encountered pharmaceutical additives. The method was found to be precise as
indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the
methods and can be used for routine analysis of pharmaceutical dosage form.
Key Words: Deferiprone, pharmaceutical dosage form, LC method

Developing a new drug from original idea to the launch of a finished product is a complex process. Numbers of
triazole derivatives as clinical drugs or candidates have been frequently employed for the treatment of various
types of diseases, which have proved the importance of this heterocyclic nucleus in drug design and discovery.
Various derivatives are prepared from potassium dithio carbazinate by a four step process. The structures of
final synthesized compounds were assigned on the basis of IR spectral data. All the newly synthesized
compounds were screened for their in-vitro anti-inflammatory properties. The para amino benzaldehyde
derivatives and chlorobenzaldehyde derivatives of 1,2,4- Triazol- 3 thiols shows significant results.
Key Words: 1, 2, 4- Triazol- 3 thiols, potassium dithio carbazinate, antiinflammatory.

In the present study, an attempt to formulate in-situ gel of Travoprost for controlled ocular delivery was
undertaken. The formulation was carried out with a thermosensitive polymer Poloxamer 407 and a
mucoadhesive polymer Carbopol 934. The prepared formulations were studied for physical appearance, pH,
gelling time, gel duration, gelation temperature, viscosity, drug content, drug diffusion and other characteristics
ideally required for in situ gelling systems. FTIR studies established the compatibility of drug and selected
excipients. Stability studies as per ICH guidelines established the stability of the formulation. The study
revealed that in situ gelling system can provide a controlled ocular drug delivery of Travoprost upto 8 hours.
Key Words: 1 Travoprost, Poloxamer 407, Carbopol 934, in-situ gelling system.

The study aimed to formulate and optimize curcumin loaded liposomes. In the present study Box Behnken
design is used for optimization of curcumin liposomes. The responses obtained from the design matrix i.e.
particle size and percentage entrapment efficiency were statistically evaluated and an optimum formula was
suggested by the design expert software. The optimised formula was prepared and evaluated. Seventeen runs
formulations were prepared according to Box-Behnken design. The formulations were F1 to F17. Formulation F13, F14,
F15, F16, and F17 were fixed as the central formulation.
Key Words: Curcumin, Optimisation, Box Behnken Design, Liposomes, Entrapment Efficiency.

Morinda citrifolia, L. popularly known as Indian Noni or Indian mulberry is an ever green small tree bearing
flowers and fruits throughout the year. It belongs to family Rubiaceae. Noni is one of the important traditional
folk medicinal plants that have been used for over 2000 years in Polynesia. It has been reported to have a broad
range of therapeutic and nutritional value.. All the plant parts are used in the treatment of various diseases and
disorders. The fruit is important because of its wide range of therapeutic potentials such as anti-bacterial, antiviral,
anti-tumor, anti-helminthes, analgesic, hypertensive, anti-inflammatory and immune enhancing effects.
The total aqueous extract of Morinda citrifolia leaves show significant invitro antidiabetic activity when
compared with the standard acarbose. The in vitro antidiabetic activity was carried out by using α-amylase
inhibition method.
Key Words: Morinda citrifolia, α-amylase inhibition.

Tamarindus indica L., (Tamarind), family, Leguminosae, is tropical plant used in the indigenous system of
medicine for the treatment of various ailments. The warm leaf decoction has been used to reduce the swelling
in the joints by dipping the legs or hands in it and is more convenient to design a transdermal formulation,
which deliver medication to systemic circulation effectively. The study was aimed to develop a herbal topical
gel containing Tamarindus indica leaf extract using carbopol-940 as gelling agents and to investigate the
anti-inflammatory activity of suitable gel formulation. Gels were prepared using carbopol-940 at different
concentration (1%, 1.5% and 2%). Prepared formulations were evaluated for various physicochemical
properties like appearance, pH, spreadability and viscosity. Based on in vitro permeation study, the best gel
formulation was chosen and it was subjected to in vitro anti-inflammatory activity studies and skin irritation
studies and kept for stability studies for a period of three months. It was inferred from the result that gel
formulation was good in appearance and homogeneity. The value of spreadability indicated that these gels
were easily spreadable by small amount of shear. The preparation was stable under normal storage conditions
and complies with skin irritation test. The in-vitro anti inflammatory studies showed that the potency of the
extract was retained while formulating the gel and have a significant activity when compared to the standard
drug (Diclofenac) and its gel. Hence the newly formulated gel (TF2) can be considered as an antiinflammatory
gel. future in-vivo studies should be perform to confirm the results obtained and utilize the
formulation for health care needs.
Key Words: Tamarindus indica, Anti-inflammatory activity, carbopol-940.

Talinum fruticosum.L( Talinaceae) is a erect, stout, fleshy, perennial herb . it is used as a leaf vegetable. It
contains rich in vitamins including vitamin A and C and minerals such as iron and calcium. The present work
highlights evaluation of in-vitro anti diabetic of Talinum fruticosum. The whole plant was collected from
Kasaragod district and total methanolic extract was prepared. From the review of literature shows the presence
of flavonoids glycosides carbohydrates and protein were more concentrated to the methanolic extract. The invitro
antidiabetic activity was done by alpha amylase inhibitory method. The metholic extract shows significant
results.
Key Words: Talinum fruticosum.L, Total methanolic extract, alpha amylase.

Antimicrobial is a substance that kills or inhibit the growth of microorganisms such as bacteria, fungi, or
protozoas. Emerging and reemerging infection and spread of drug resistant strains of microorganisms are posing
a challenge to global public health in terms of treatment. There is increasing interest in the use of plant extracts
as therapeutic agent to inhibit the growth of pathogenic micro organisms. Chassalia curviflora is an evergreen
shrub grows in tropical region and is endemic to East Asia. It has potential uses like anti hypertensive, anti
bacterial and traditionally used for eye infection, ear infection and insect bites. The present study highlights the
antibacterial studies of Methanolic and Aqueous extracts of leaves of Chassalia curviflora. The phytochemical
screening of the plant extracts shows the presence of various chemical constituents such as alkaloids, phenolics,
flavanoids and saponins. These may be responsible for the anti bacterial activity.
Key Words: Chassalia curviflora, antibacterial.

Inflammation is a defense phenomenon yet often leading to serous pathological conditions. From ancient days
human used the traditional medicinal plants as anti-inflammatory agent. “Utricularia reticulata” is such a plant
which is used by the tribes for the treatments of ulcers, wound healing, and neutralizing venoms of snakes,
spiders, eye diseases. The study highlights the anti inflammatory studies of the plant thereby increasing the
utilization of this commonly available plant for its medicinal property. The whole plants were collected, dried
and subjected to successive solvent extraction. The phtyochemical screening were carried out. Further the
extracts were tried for anti inflammatory studies. Chloroform and acetone extracts were shown significant anti
inflammatory properties. Inspite of the data reveled form phytochemical screening and literature survey the
phytoconstituents like alkaloids, glycosides, phenolic and flavonoids, flavonones, terpenoids and sterols present
in the plant were responsible for the activities.
Keywords: Utricularia reticulata, antioxidant, antibacterial.

The aim of the present study is to evaluate acute toxicity and anti urolithic activity of aqueous extract of
Tamirindus Indica seeds. the plant extract clearly exibit anti urolithiatic effect against Ammonium chloride and
Ethylen Glycol induced urolithiasis in Albino rats. The study results also indicates dose dependent anti
urolithiatic activity of Tamarinds Indica Seed extract.
Key Words: Tamirindus Indica, anti urolithiatic activity, seed extract

Studies were conducted for the preparation of Bilayer floating formulations of Carvedilol. Solubility studies
showed Carvedilol, highly soluble in methanol acidic pH but poorly soluble in water. FTIR studies showed no
incompatibility between drug, polymer and various excipients used in the formulations. Formulated tablets
gave satisfactory results for various evaluation parameters like tablet dimensions, hardness, weight variation,
friability, content uniformity, swelling index, in vitro buoyancy properties and in vitro drug release. In tablet
formulations F3, F5, F8 and F11 gave better controlled drug release and floating properties in comparison to
the other formulations.F8 is release 98.33% in 12hrs and float for 12hrs and other parameters like hardness,
thickness,assay,friability all within limits and well satisfactory. The drugs release from the optimised tablets
was sufficiently sustained and fickian transport of drugs from tablets was confirmed as the release exponent
value was less than 0.5. In vivo radiographic studies of single unit tablets (F8) indicated that the tablets
remained in the stomach for 6h, which indicates the increase in the GRT is due to floating and swelling
principle
Key Words: Carvedilol, Bilayer floating formulations