Salbutamol sulphate (SS), a directly acting sympathomimetic drug, is a good candidate for sustained release
formulations due to its short half-life but it is challenging because of its high water solubility. The aim of this
work is to design oral sustained release tablets of using hydrophilic polymers, and thus increasing patient
compliance by reducing its frequency of administration. Tablets were prepared by wet granulation technique
using hydroxypropyl methylcellulose (HPMCK-15), ethylcellulose (EC), carbopol (C940), cellulose acetate
phthalate, cetosteryl alcohol (CSA). The compatibility of the drug with the various used excipients was studied
using FTIR. The effects of polymer concentration, polymer viscosity and binary mixtures of some polymers on
the in vitro drug release were studied. Results of FT-IR confirmed drug-excipients compatibility. The different
prepared tablet formulae exhibited content uniformity within the acceptable limit and showed good mechanical
properties. It was found that the in-vitro dissolution profile of salbutamol from tablets containing
E.C(5%),C.S.A(10%),HPMC K-15(10%),C.940(5%) formula no. F-12 is almost similar with that of marketed
product (salowin-SR).The stability studies showed that the drug content for the best formulation remained same
even after storing for three month at different temperatures with a very minute standard deviation.

Pyrazoline are prominent nitrogen containing heterocyclic compounds posses various pharmacological activities.
In our study we synthesized pyrazoline-5-one derivatives. Synthesized compounds were characterized by using
UV, IR and 1H NMR. Characterized compounds were screened for Anti depressant activity was by force swim test
method. Compound 2 and 5 posses potent antidepressant activity.

Taking food every day is man’s common practice. Food helps him to sustain his life and continue doing regular
activities. He is said to have observed a fast on the day when he abstains from food for one reason or another. Fast
has absolutely nothing to do with religion. It is true that on certain religious occasions we observe a fast by taking
or abandoning certain food-items, but it cannot be called fasting in its true sense or from the scientific point of
view. On the fast-day, compelled by religious sentiment, we keep control over our natural desire and avoid taking
regular food (particularly made from cereals). However, in its substitution, we take other nutritious and heavy
foods like milk and milk-products.

A simple UV-Spectroscopic method was developed and validated for analysis of Clopidogrel formulation.
Clopidogrel, an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to inhibit blood
clots in a variety of conditions such as peripheral vascular disease, coronary artery disease, and cerebrovascular
disease. The drug samples were analyzed by UV spectroscopy using 0.1 n HCL as solvent. The average content
of drug present in the formulation was found to be 74.71 mg (99.62%). The percentage recovery of clopidogrel
sample was found within the limit 96.48%- 105.76%.

Transgenesis is the process of introducing an exogenous gene called a transgene into a living organism so that the
organism will exhibit a new property and transmit that property to its offspring. Transgenesis can be facilitated by
liposomes, plasmid vectors, viral vectors, pronuclear injection, protoplast fusion, and ballistic DNA injection. This
article reviews about the history, techniques and application about transgenic animals, which is useful for the
researchers as the preliminary information.

A simple precise and reliable UV-Visible spectroscopic process was developed for the quantitative determination
or estimation of olanzepine an antipsychotic, neuroleptic. This drug was developed a easy, particular and
dependable UV spectroscopic method from the quantitative estimation of olanzepine and its validation
parameters like linearity, precision, ruggedness, robustness, limit of detection (LOD) and limit of quantification
(LOQ) are conducted and standard truthfulness to International conference of harmonization guidelines. Water:
HCl (9:1) was elected as the solvent system and UV spectroscopic method determination carried out and at a
highest absorption at about 310 nm using above solvent system. In this process linearity of olanzepine was found
to be 5-45μg/ml with co-relation coefficient 0.989 respectively. The percentage of relative standard deviation
(RSD) value for both intraday and interday precision was less than 1%. The recovery of the drug from the sample
was ranged between 99.6-101.1% while estimation the commercial formulation was no interference of excipients
and other additives. Hence this method can be used for the routine determination of olanzepine in bulk and
pharmaceutical dosage forms and proposed method for study of stability shows that there was applicable
degradation found in stress condition of olanzepine.

The study aimed to evaluate the effect of different solvents in estimation of total phenolic content, flavanoid content and antioxidant properties of Phyllantus niruri. Phyllantus niruri as a whole plant is a popular folkfore medicine and are used in the treatment of various diseases especially in hepatitis and other viral infection. Phenolic content of extracts were determined using Folin-Ciocalteu assays, total flavanoid content was estimated by vanillin reagent method and invitro antioxidant activity was carried out by DPPH method. The results showed that different solvent with different polarity possess significant effect on total phenolic, total flavanoid and antioxidant activities.

Herbal medicine has become an item of global importance both medicinal and economical. Although usage of these herbal medicines has increased, their quality, safety and efficiency are serious concerns in industrialized and developing countries. The present research has been undertaken with the aim to formulate and evaluate the herbal gel containing Mimusops elengi Linn., fruits extract. The gel formulation was designed by using Carbapol 940, Mimusops elengi Linn., fruits extract, propylene glycol, methyl paraben, propyl paraben and required amount of distilled water. The skin pH (6.8-7.1) was maintained by drop wise addition of Tri-ethanolamine. The physicochemical Parameters of formulations (pH, Spreadibility, Stability etc.) were determined. Stability studies have carried out as per ICH guidelines for 3 months at different temperatures and humidity. The results showed that formulation containing Mimusops elengi Linn., fruits extract Show better stability. Further formulations have studied for skin irritation on animal model (Rat) and result showed that there was no skin irritation to animals.

Aegle marmelos, commonly known as bael, Bengal quince, golden apple, stone apple, wood apple, bili, is a species of tree native to India. In the system of Ayurveda this drug was used in a number of diseases such as gastro intestinal diseases, piles, oedema, jaundice, vomiting, obesity, pediatric disorders, gynecological disorders, urinary complaints and as a rejuvenative. In our research we evaluated the antidiabetic activity of the fruits of Aegle marmelos by glycosylated haemoglobin method and found the pant fruit having potent activity.
Keywords: Aegle marmelos, Ayurveda drug, glycosylated haemoglobin method, Antidiabetic activity.